Types of Closures for Chromatography Vials

 


Chromatography vials come in many shapes and sizes, depending on the compounds to be separated. Sizes vary depending on the compound volatility and stability, and the type of autosampler used. The type of insert used in the autosampler also affects sample recovery. The conical type features a tapered bottom and pulled tips. Flat vials are flat, with a flat bottom and the greatest capacity. Read through this blog to learn more about chromatography vials. 

 

Cylindrical chromatography vials have screw thread closures, which are widely compatible with most autosamplers. Screw-thread closures are convenient to use and come in many colors and septum materials. They meet analytical purity and tightness requirements while minimizing the risk of penetration. Crimp caps are also popular for HPLC and GC. Depending on the method of analysis, these vials may be used for both liquid and gas chromatography.

 

For organic samples, black phenolic screw caps with PTFE-faced 14B rubber lines are used. Replacement caps are available separately. Both types of caps can be autoclaved. If you require glass vials with a large opening, you can opt for clear or amber glass vials. You can find these with a write-on spot to facilitate sample identification. Similarly, you can find bulk VIALS and convenience kits.

 

While selecting the type of closure, keep in mind that it must be compatible with the sample. In most cases, amber glass vials are used for light-sensitive samples while plastic polypropylene vials are used for solutions sensitive to glass. Check out this website for more info. The type of closure will also affect sample recovery. Generally, there are three types of closures for chromatography vials: screw cap, crimp, and snap closure.

 

The type of closures used in chromatography vials is a key factor in the performance of analytical methods. Screw-cap vials are preferred for GC with volatile compounds, while crimp-cap vials are preferred for HPLC and LCMS applications. Snap caps are easy to use and are ergonomically designed for lab technicians. They are also compatible with other brands of vials, such as National Scientific, Chromacol, and Sun-Sri caps.

 

The septum in chromatography vials is made of silicone or PTFE. Silicone is chemically inert, allowing it to withstand extreme temperatures while maintaining flexibility. It is resistant to UV radiation, which makes it compatible with multiple sterilization methods. PTFE/silicone septums are typically preferred for chromatography applications. Silicone septas are not reusable. You should avoid using punctured PTFE vials for long-term storage.

 

The size of the vials used for chromatography is also important. Standard chromatography vials are 12x32 mm (2.4mL), and 15x45mm (4.8mL). There are also two types of mouth openings: normal (4 mL) and wide (6 mL. Also, the type of cap is important. A 9-mm vial cap is used for samples handled by a robotic arm machine, whereas a smaller sample requires a Limited Volume Vial. The materials used in chromatography vials vary, as well as the size, shape, and type of closure.

 

For high-quality chromatography vials, polypropylene is recommended. These types are non-porous, reducing the risk of contamination or evaporation. They are also sustainable, made from abundant raw materials, and have a high melting point. Amber glass vials also protect samples from ultraviolet light. Those with light-sensitive samples should choose amber-tinted vials. Want to read more about the article? Browse here now: https://www.dictionary.com/browse/chromatogram.